BONNIE BASSLER | BASSLER LAB | bacterial disease | chemicals
Genius At Work
by
Tracy Staton
"Ahhh," she says, inhaling deeply. "Smells like fish poop."
THE BASSLER LAB started out translating
V. harveyi's communications, but now it's
teasing apart the language spoken by the entire bacterial family
tree. Several years ago, Bassler and her lab associates discovered
that one of the
chemicals V. harveyi uses
to communicate is also used by hundreds of other species - in fact,
by most species they've tested.
The
chemical is known as auto-inducer 2 (AI-2), a rather bland,
pedestrian name for a substance that could eventually cure cholera,
strep, staph - any bacterial disease, anywhere in the world.
The potential that's there is why Bassler and the 18 students and
employees who work in her lab spend hundreds of hours a week
digging into the minute workings of AI-2 (and its cousins
auto-inducers 1 and 3). And it's also why she's a scientific
celebrity, the sort of scientist who, when appearing at
conferences, inspires a chorus of whispers. Like
V. harveyi when it's about to glow, people signal to
each other, pointing and saying,
"There she is:
Bonnie Bassler. Should we talk to her? Let's talk to her."
A bit ironically - but only a bit - Bassler drinks from a coffee
mug inscribed "Diva." She doesn't consider the label insulting; she
embraces it. Diva behavior gets results. She's officially a genius
now, thanks to the "genius grant" bestowed on her by the John D.
and Catherine T. MacArthur Foundation, so why not put the diva
personality trait to work?
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